Updated May 2019
Researcher ID: I-2767-2012
Google Scholar ID: Link
ORCID: Link
2025
[65] Carolin Hermanns, Rick H.W. de Vries, Timo Rademakers, Adam Stell, Denise F.A. de Bont, Omar Paulino da Silva Filho, Marlon J. Jetten, Carlos D. Mota, Sami G. Mohammed, Vijayaganapathy Vaithilingam, Aart A. van Apeldoorn, Assessing mesh size and diffusion of alginate bioinks: A crucial factor for successful bioprinting functional pancreatic islets, Materials Today Bio, Volume 34, 2025, 102175, ISSN 2590-0064, https://doi.org/10.1016/j.mtbio.2025.102175.
[64] Adam Stell, Vijayaganapathy Vaithilingam, Sami G. Mohammed, Rick H.W. de Vries, Denise F.A. de Bont, Eelco J.P. de Koning, Aart A. van Apeldoorn, A hybrid implant combining a macroporous device with immunoprotective microcapsules for cell therapy applications: A conceptual in vitro study, Materials Today Bio, Volume 31, 2025, 101574, ISSN 2590-0064
[63] Tol MC, de Vries RHW, Engelse MA, et al. Subcutaneous Implantation of Open Microwell Islet Delivery Devices in Pigs. Surgical Innovation 2024;32(2):141-148. doi:10.1177/15533506241306491
[62] de Bont DFA, Mohammed SG, de Vries RHW, Paulino da Silva Filho O, Vaithilingam V, Jetten MJ, Engelse MA, de Koning EJP., van Apeldoorn AA (2025) Supporting islet function in a PVDF membrane based macroencapsulation delivery device by solvent non-solvent casting using PVP. PLoS ONE 20(3): e0298114. https://doi.org/10.1371/journal.pone.0298114
2023
[61] de Vries, R., van Apeldoorn, A.A. (2023). Scaffolds for Encapsulation of Stem Cell-Derived β Cells. In: Piemonti, L., Odorico, J., Kieffer, T.J..., Sordi, V., de Koning, E. (eds) Pluripotent Stem Cell Therapy for Diabetes. Springer, Cham. https://doi.org/10.1007/978-3-031-41943-0_7
[60] de Vries, R., van Apeldoorn, A.A. (2023). Selecting Biocompatible Biomaterials for Stem Cell-Derived β-Cell Transplantation. In: Piemonti, L., Odorico, J., Kieffer, T.J..., Sordi, V., de Koning, E. (eds) Pluripotent Stem Cell Therapy for Diabetes. Springer, Cham. https://doi.org/10.1007/978-3-031-41943-0_6
[59] Tol MC, de Bont DFA, Boon WPC, de Koning EJP and van Apeldoorn AA (2023) Preferred Islet Delivery Device Characteristics and Implantation Strategies of Patients With Type 1 Diabetes. Transpl Int 36:11077. doi: 10.3389/ti.2023.11077
[58] S. Abadpour, E. M. Niemi, L. S. Orrhult, C. Hermanns, R. de Vries, L. P. Nogueira, H. J. Haugen, D. Josefsen, S. Krauss, P. Gatenholm, A. van Apeldoorn, H. Scholz, Adipose-Derived Stromal Cells Preserve Pancreatic Islet Function in a Transplantable 3D Bioprinted Scaffold. Advanced Healthcare Materials2023, 12,2300640. https://doi.org/10.1002/adhm.202300640
[57] Piemonti L, Scholz H, de Jongh D, Kerr-Conte J, van Apeldoorn A, Shaw JAM, Engelse MA, Bunnik E, Mühlemann M, Pal-Kutas K, Scott WE, Magalon J, Kugelmeier P and Berishvili E (2023) The Relevance of Advanced Therapy Medicinal Products in the Field of Transplantation and the Need for Academic Research Access: Overcoming Bottlenecks and Claiming a New Time. Transpl Int 36:11633. doi: 10.3389/ti.2023.11633
2022
[56] Abadpour, S., Niemi, E.M., Orrhult, L.S., Hermanns, C., de Vries, R., Parreiras Nogueira,L., Haugen, H.J., Josefsen,D., Krauss, S., van Apeldoorn, A., Gatenholm,P. Scholz, H., Adipose-derived stromal cells preserve pancreatic islet function in a transplantable 3D bioprinted scaffold, bioRxiv 2022.05.30.494035; doi: https://doi.org/10.1101/2022.05.30.494035
[55] Stell, A. L., Mohammed,S.G., de Vries, R., Engelse, M.A., de Koning, E.J.P., Sthijns, M.M.J.P.E., LaPointe, V.L.S., van Apeldoorn, A. A. Systematic evaluation of clinically used biomaterials to determine their suitability for fabrication of beta cell delivery devices, Journal of Immunology and Regenerative Medicine. Volume 16, 2022, 100055, ISSN 2468-4988, https://doi.org/10.1016/j.regen.2021.100055.
[54] Hermanns, C., da Silva Filho, O.P., Vaithilingam, V., van Apeldoorn A. A. The Potential of Cell Sheet Technology for Beta Cell Replacement Therapy. Curr Transpl Rep 9, 199–208 (2022). https://doi.org/10.1007/s40472-022-00371-4
2021
[53] Reys, L. L., Vaithilingam, V., Sthijns, M. M. J. P. E., Soares, E., Rademakers, T., de, R., Mohammed, S. G., de, D., Jetten, M. J., Hermanns, C., da Silva, O. P., Stell, A., Mourad, N. I., Gianello, P., LaPointe, V. L. S., Silva, S. S., Reis, R. L., Silva, T. H., van Apeldoorn, A. A., Fucoidan Hydrogels Significantly Alleviate Oxidative Stress and Enhance the Endocrine Function of Encapsulated Beta Cells. Adv. Funct. Mater. 2021, 2011205. https://doi.org/10.1002/adfm.202011205.
[52] Sthijns MMJPE , Jetten MJ, Mohammed SG, Claessen SMH, de Vries R, Stell A, de Bont D, Engelse MA, Mumcuoglu D, van Blitterswijk CA, Dankers PYW, de Koning EJP, van Apeldoorn AA, LaPointe VLS, Oxidative stress in alpha and beta cells as a selection criterion for biocompatible biomaterials, Biomaterials, Vol 267, 2021, 120449, https://doi.org/10.1016/j.biomaterials.2020.120449
2020
[51] de Vries R, Stell A, Mohammed S, Hermanns C, Helvia Martinez A, Jetten M, van Apeldoorn A, Chapter 33 Bioengineering, biomaterials, and β-cell replacement therapy, Ed(s): Orlando G, Piemonti L, Ricordi C, Stratta RJ, Gruessner RWG, Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Academic Press, (2020), 461-486, ISBN 9780128148310, doi.org/10.1016/B978-0-12-814831-0.00033-6.
2019
[50] Hadavi E, Leijten J, Engelse M, de Koning E, Jonkheijm P, Karperien M, van Apeldoorn A, Microwell Scaffolds Using Collagen-IV and Laminin-111 Lead to Improved Insulin Secretion of Human Islets Tissue Engineering Part C: Methods.Feb 2019. ahead of print: http://doi.org/10.1089/ten.tec.2018.0336
2018
[49] Groot Nibbelink M, Skrzypek K, Karbaat L, Both S, Plass J, Klomphaar B, van Lente J, Henke S, Karperien M, Stamatialis D, van Apeldoorn A, An important step towards a prevascularized islet microencapsulation device: in vivo prevascularization by combination of mesenchymal stem cells on micropatterned membranes, J Mater Sci: Mater Med. 2018 29: 174. https://doi.org/10.1007/s10856-018-6178-6
[48] Hadavi E, Leijten J, Brinkmann J, Jonkheijm P, Karperien M, and van Apeldoorn A, Fibronectin and Collagen IV Microcontact Printing Improves Insulin Secretion by INS1E Cells, Tissue Engineering Part C: Methods.Nov 2018. ahead of print: http://doi.org/10.1089/ten.tec.2018.0151
[47] Skrzypek K, Groot Nibbelink M, Karbaat LP, Karperien M, van Apeldoorn AA, Stamatialis D, An important step towards a prevascularized islet macroencapsulation device, effect of micropatterned membranes on development of endothelial cell network, J.Mater.Sci:Mater.Med. 2018, 29: 91. DOI: doi.org/10.1007/s10856-018-6102-0
2017
[46] Marchioli G, Zellner L, Oliveira C, Engelse M, de Koning E, Mano J, Karperien M, van Apeldoorn A, Moroni L, Layered PEGDA hydrogel for islet of Langerhans encapsulation and improvement of vascularization, J Mater Sci: Mater Med. 2017; 28:195. DOI: 10.1007/s10856-017-6004-6
[45] Skrzypek K, Groot Nibbelink M,van Lente J, Buitinga M, Engelse MA, de Koning EJP, Karperien M, van Apeldoorn AA, Dimitrios Stamatialis, Pancreatic islet macroencapsulation using microwell porous membranes, Scientific Reports. 2017; 7(1): Article number: 9186. DOI: 10.1038/s41598-017-09647-7
[44] Buitinga M, Assen F, Hanegraaf M, Wieringa P, Hilderink J, Moroni L, Truckenmüller R, van Blitterswijk C, Römer GW, Carlotti F, de Koning E, Karperien M, van Apeldoorn A. Micro-fabricated scaffolds lead to efficient remission of diabetes in mice, Biomaterials. 2017; 135: 10-22. DOI: 10.1016/j.biomaterials.2017.03.031
[43] Smink AM, Li S, Swart HD, Hertsig DT, de Haan BJ, Kamps JAAM, Schwab L, van Apeldoorn AA, de Koning E, Faas MM, Lakey JRT, de Vos P. Stimulation of vascularization of a subcutaneous scaffold applicable for pancreatic islet-transplantation enhances immediate post-transplant islet graft function but not long-term normoglycemia, Journal of Biomedical Materials Research Part A. 2017; 105(9): 2533–2542. DOI: 10.1002/jbm.a.36101
[42] Smink AM, Li S, Hertsig DT, de Haan BJ, Schwab L, van Apeldoorn AA, de Koning E, Faas MM, Lakey JRT, de Vos P. The efficacy of a prevascularized, retrievable Poly(D,L,-lactide-co-ε-caprolactone) subcutaneous scaffold as transplantation site for pancreatic islets, Transplantation. 2017; 101(4): e112–e119. DOI: 10.1097/TP.0000000000001663
2016
[41] Groot Nibbelink M, Marchioli G, Moroni L, Karperien M, van Apeldoorn AA, Protocol to Enhance INS1E and MIN6 Functionality—The Use of Theophylline. Int. J. Mol. Sci. 2016, 17, 1532. https://doi.org/10.3390/ijms17091532
[40] Henke S, Leijten J, Kemna E, Neubauer M, Fery A, van den Berg A, van Apeldoorn A, Karperien M. Enzymatic Crosslinking of Polymer Conjugates is Superior over Ionic or UV Crosslinking for the On-Chip Production of Cell-Laden Microgels. Macromolecular Bioscience. 2016 Jul 21. [Epub ahead of print]. DOI: 10.1002/mabi.201600174
[39] Smink AM, Hertsig DT, Schwab L, van Apeldoorn AA, de Koning E, Faas MM, de Haan BJ, de Vos P. A Retrievable, Efficacious Polymeric Scaffold for Subcutaneous Transplantation of Rat Pancreatic Islets. Annals of Surgery 2016 Jul 15.
[38] Marchioli G, Luca AD, de Koning EJP, Engelse M, van Blitterswijk CA, Karperien M, van Apeldoorn AA, Moroni L. Hybrid polycaprolactone/alginate scaffolds functionalized with VEGF to promote de novo vessel formation for the transplantation of islets of Langerhans. Advanced Healthcare Materials 2016. In Press. DOI: 10.1002/adhm.201600058
[37] Smink AM, de Haan BJ, Paredes-Juarez GA, Wolters AHG, Kuipers J, Giepmans BNG, Schwab L, Engelse MA, van Apeldoorn AA, de Koning EJP, Faas MM, de Vos P. Selection of polymers for application in scaffolds applicable for human pancreatic islet transplantation. Biomedical Materials 2016; 11(3): 35006–35016.
[36] Groot Nibbelink M, Daoudi K, Slegers S, Grootendorst D, Dantuma M, Steenbergen W, Karperien M, Manohar S, van Apeldoorn AA. Opening the “white box” in tissue engineering: visualization of cell aggregates in optically scattering Scaffolds. Tissue Engineering Part C: Methods 2016. In Press. DOI:10.1089/ten.tec.2015.0462
2015
[35] Buitinga M, Janeczek Portalska K, Cornelissen D, Plass J, Hanegraaf M, Carlotti F, de Koning EJP, Engelse MA, van Blitterswijk CA, Karperien M, van Apeldoorn AA, de Boer J. Coculturing human islets with proangiogenic support cells to improve islet revascularization at the subcutaneous transplantation site. Tissue Engineering Part A 2016; 23(3-4): 375–385.
[34] Steins A, Dik P, Müller WH, Vervoort SJ, Reimers K, Kuhbier JW, Vogt PM, van Apeldoorn AA, Coffer PJ, Schepers K. In vitro evaluation of spider silk meshes as a potential biomaterial for bladder reconstruction. PLOS One 2015; 10(12): e0145240.
[33] Marchioli G, van Gurp L, van Krieken PP, Stamatialis D, Engelse M, van Blitterswijk CA, Karperien M, de Koning E, Alblas J, Moroni L, van Apeldoorn AA. Fabrication of three-dimensional bioplotted hydrogel scaffolds for islets of Langerhans transplantation. Biofabrication 2015; 7: 025009.
[32] Hujaya SD, Marchioli G, Roelofs K, van Apeldoorn AA, Moroni L, Karperien M, Paulusse JMJ, Engbersen JFJ. Poly(amido amine)-based multilayered thin films on 2D and 3D supports for surface-mediated cell transfection. Journal of Controlled Release 2015; 205,:181–189
[31] Manohar S, van Apeldoorn A, Steenbergen W. Photoacoustic imaging: Cells make themselves heard. Nature Photonics 2015; 9(215): 216–218.
[30] Hilderink J, Spijker S, Carlotti F, Lange L, Engelse M, van Blitterswijk C, de Koning E, Karperien M, van Apeldoorn A. Controlled aggregation of primary human pancreatic islet cells leads to glucose-responsive pseudoislets comparable to native islets. Journal of Cellular and Molecular Medicine 2015; 19(8): 1836–1846.
2014
[29] Gevaert E, Dolle ́ L, Billiet T, Dubruel P, van Grunsven L, van Apeldoorn A, Cornelissen R. High throughput micro-well generation of hepatocyte micro-aggregates for tissue engineering. PLOS ONE 2014; 9(8): e105171.
2013
[28] Hilderink J, Otto C, Slump C, Lenferink A, Engelse MA, van Blitterswijk CA, de Koning EJP, Karperien M, vanApeldoorn AA. Label-free detection of insulin and glucagon within human islets of Langerhans using Raman spectroscopy. PLOS ONE 2013; 8(10: e78148.
[27] Buitinga M, Truckenmüller R, Engelse MA, Moroni L, ten Hoopen HWM, van Blitterswijk CA, de Koning EJP, van Apeldoorn AA, Karperien M. Microwell scaffolds for the extrahepatic transplantation of islets of Langerhans. PLOS ONE 2013; 8(5): e64772.
[26] Kunstar A, Leferink AM, Okagbare PI, Morris MD, Roessler BJ, Otto C, Karperien M, van Blitterswijk CA, Moroni L, van Apeldoorn AA. Label-free Raman monitoring of extracellular matrix formation in three-dimensional polymeric scaffolds. Journal of The Royal Society Interface 2013; 10(86):20130464.
[25] Spijker HS, Ravelli RBG, Mieke Mommaas-Kienhuis A, van Apeldoorn AA, Engelse MA, Zaldumbide A, Bonner-Weir S, Rabelink TJ, Hoeben RC, Clevers H, Mummery CL, Carlotti F, de Koning EJP. Conversion of mature human beta-cells into glucagon-producing alpha-cells. Diabetes 2013; 62(7):2471-80.
[24] Masaeli E, Morshed M, Hossein Nasr-Esfahani M, Sadri S, Hilderink J, van Apeldoorn A, van Blitterswijk CA, Moroni L. Fabrication, characterization and cellular compatibility of poly(hydroxyl alkanoate) composite nanofibrous scaffolds for nerve tissue engineering. PLOS ONE 2013; 8(2):e57157.
[23] Doorn J, Roberts SJ, Hilderink J, Groen N, van Apeldoorn A, van Blitterswijk C, Schrooten J, de Boer J. Insulin-like-growth-factor-I enhances proliferation and differentiation of human mesenchymal stromal cells in vitro. Tissue Engineering Part A 2013; 19(15-16):1817–1828.
[22] Spitters TWGM, Leijten JCH, Deus FD, Costa IBF, van Apeldoorn AA, van Blitterswijk CA, Karperien HJB. A dual flow bioreactor with controlled mechanical stimulation for cartilage tissue engineering. Tissue Engineering Part C-Methods 2013; 19(10):774–783.
2012
[21] Basalus MWZ, Tandjung K, Sen H, van Apeldoorn AA, Grijpma DW, von Birgelen C. Recent insights from scanning electron microscopic assessment of durable polymer-coated drug-eluting stents. Interventional Cardiology 2012; 4(6):661-674.
[20] Lourenco BN, Marchioli G, Song W, Reis RL, van Blitterswijk CA, Karperien M, van Apeldoorn A, Mano JF. Wettability influences cell behavior on superhydrophobic surfaces with different topographies. Biointerfaces 2012; 7(1-4):46.
[19] Berenschot EJ, Burouni N, Schurink B, van Honschoten JW, Sanders RG, Truckenmuller R, Jansen HV, Elwenspoek MC, van Apeldoorn AA, Tas NR. 3D Nanofabrication of fluidic components by corner lithography. Small 2012; 8(24):3823–3831.
[18] Kunstar A, Leijten J, van Leuveren S, Hilderink J, Otto C, van Blitterswijk CA, Karperien M, van Apeldoorn AA. Recognizing different tissues in human fetal femur cartilage by label-free Raman microspectroscopy. Journal of Biomedical Optics 2012; 17(11):116012.
[17] Moreira Teixeira LS, Leijten JCH, Sobral J, Jin R, van Apeldoorn AA, Feijen J, van Blitterswijk C, Dijkstra PJ, Karperien M. High throughput generated micro-aggregates of chondrocytes stimulate cartilage formation in vitro and in vivo. European Cells & Materials Journal 2012; 34:387-399.
[16] Lopez-Heredia MA, Sariibrahimoglu K, Yang W, Bohner M, Yamashita D, Kunstar A, van Apeldoorn AA, Bronkhorst EM, Lanao RP, Leeuwenburgh SC, Itatani K, Yang F, Salmon P, Wolke JG, Jansen JA. Influence of the pore generator on the evolution of the mechanical properties and the porosity and interconnectivity of a calcium phosphate cement. Acta Biomaterialia 2012; 8(1):404-414.
[15] Basalus MW, Tandjung K, van Westen T, Sen H, van der Jagt PK, Grijpma DW, van Apeldoorn AA, von Birgelen C. Scanning electron microscopic assessment of coating irregularities and their precursors in unexpanded durable polymer-based drug-eluting stents. Catheterization and Cardiovascular Interventions 2012; 79(4):644-653.
2011
[14] Hazekamp J, Reed MG, Howard CV, van Apeldoorn AA, Otto C. The feasibility of Cryo In-SEM Raman microspectroscopy. Journal of Microscopy 2011; 244(2):122–128.
[13] Kunstar A, Otto C, Karperien M, van Blitterswijk C, van Apeldoorn A. Raman microspectroscopy: a noninvasive analysis tool for monitoring of collagen-containing extracellular matrix formation in a medium- throughput culture system. Tissue Engineering Part C- Methods 2011;17(7):737–744.
[12] Basalus MWZ, Tandjung K, van Apeldoorn AA, Ankone MJK, Birgelen von C. Effect of oversized partial postdilatation on coatings of contemporary durable polymer-based drug-eluting stents: a scanning electron microscopy study. Journal of Interventional Cardiology 2011; 24(2):149–161.
[11] Both SK, van Apeldoorn AA, Jukes JM, Englund MC, Hyllner J, van Blitterswijk CA, de Boer J. Differential bone-forming capacity of osteogenic cells from either embryonic stem cells or bone marrow-derived mesenchymal stem cells. Journal of Tissue Engineering and Regenerative Medicine 2011; 5(3):180–190.
2007 and earlier
[10] van Manen H-J, van Apeldoorn AA, Verrijk R, van Blitterswijk CA, Otto C. Intracellular degradation of microspheres based on cross-linked dextran hydrogels or amphiphilic block copolymers: a comparative raman microscopy study. International Journal of Nanomedicine 2007; 2(2):241–252.
[9] van Apeldoorn AA, de Boer J, van Steeg H, Hoeijmakers JHJ, Otto C, van Blitterswijk CA. Physicochemical composition of osteoporotic bone in the trichothiodystrophy premature aging mouse determined by confocal Raman microscopy. Journal of Gerontology: Medical Sciences 2007; 62(1):34–40.
[8] van Manen H-J, van Apeldoorn AA, Roos D, Otto C. Raman microscopy of phagocytosis: shedding light on macrophage foam cell formation. SPIE Proceedings 2006; 6093:122–130.
[7] Wang J, van Apeldoorn A, de Groot K. Electrolytic deposition of calcium phosphate/chitosan coating on titanium alloy: growth kinetics and influence of current density, acetic acid, and chitosan. Journal of Biomedical Materials Research Part A 2006; 76(3):503–511.
[6] van Apeldoorn AA, Aksenov Y, Stigter M, Hofland I, de Bruijn JD, Koerten HK, Otto C, Greve J, van Blitterswijk CA. Parallel high-resolution confocal Raman SEM analysis of inorganic and organic bone matrix constituents. Journal of the Royal Society: Interface 2005; 2(2):39–45.
[5] van Apeldoorn AA, van Manen H-J, Bezemer JM, de Bruijn JD, van Blitterswijk CA, Otto C. Raman imaging of PLGA microsphere degradation inside macrophages. Journal of the Americal Chemical Society 2004; 126(41):13226–13227.
[4] de Boer J, Siddappa R, Gaspar C, van Apeldoorn A, Fodde R, van Blitterswijk C. Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells. Bone 2004; 34(5):818–826.
[3] Deschamps AA, van Apeldoorn AA, Hayen H, de Bruijn JD, Karst U, Grijpma DW, Feijen J. In vivo and in vitro degradation of poly(ether ester) block copolymers based on poly(ethylene glycol) and poly(butylene terephthalate). Biomaterials 2004; 25(2):247–258.
[2] Deschamps AA, van Apeldoorn AA, de Bruijn JD, Grijpma DW, Feijen J. Poly(ether ester amide)s for tissue engineering. Biomaterials 2003; 24(15):2643–2652.
[1] Alonso A, van Apeldoorn A, Banuelos M, Barrutia MG, Zapata ZG. Antibody-forming cells (AFCs) in the lung lymphoid tissue after primary and secondary immunization through different routes: a semiquantitative analysis in adult rats using T-dependent (TNP-KLH) and T-independent antigens (TNP-LPS). Advances in Experimental Medicine and Biology 1994; 355:277–281.
Book Chapters
[3] Rick de Vries, Adam Stell, Sami Mohammed, Carolin Hermanns, Adela Helvia Martinez, Marlon Jetten, Aart van Apeldoorn, Chapter 33 - Bioengineering, biomaterials, and β-cell replacement therapy, Editor(s): Giuseppe Orlando, Lorenzo Piemonti, Camillo Ricordi, Robert J. Stratta, Rainer W.G. Gruessner, Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Academic Press, 2020, Pages 461-486, ISBN 9780128148310, https://doi.org/10.1016/B978-0-12-814831-0.00033-6.
[2] R. van Dijkhuizen-Radersma, L. Moroni, Z. Zhang, A.A. van Apeldoorn, D. Grijpma. “Degradable polymers for tissue engineering”, In: Tissue engineering, C.A. van Blitterswijk (Ed), Elsevier, pp 193-222 (2008).
[1] S.C. Mendes, J.D. de Bruijn, K. Bakker, A.A. van Apeldoorn, P.P. Platenburg, G.J.M. Tibbe and C.A. van Blitterswijk, "Human bone marrow stromal cells for bone tissue engineering: In vitro and in vivo characterisation", In: Bone Engineering, JE Davies (Ed), EM Square Inc., Toronto, pp. 505-515 (2000).