Updated October 2016

Researcher ID: I-2767-2012
Google Scholar ID: Link


45 . 
  • Skrzypek K, 
  • Groot Nibbelink M, 
  • Karbaat LP, Karperien M,
  •  van Apeldoorn AA
  • Stamatialis D,  
  • An important step towards a prevascularized islet macroencapsulation device,  effect of micropatterned membranes on development of endothelial cell network, J Mater Sci: Mater Med (2018) 29: 91. DOI: doi.org/10.1007/s10856-018-6102-0

  • 44. Marchioli G,  
  • Zellner L, 
  • Oliveira C, 
  • Engelse M, 
  • de Koning E, 
  • Mano J, 
  • Karperien M, 
  • van Apeldoorn A,
  •  Moroni L, 
  • Layered PEGDA hydrogel for islet of Langerhans encapsulation and improvement of vascularization, J Mater Sci: Mater Med. 2017; 28:195. DOI: 10.1007/s10856-017-6004-6

    43. Skrzypek K, Groot Nibbelink M, van Lente J, Mijke Buitinga M, Engelse MA, de Koning EJP, Karperien M, van Apeldoorn AA Stamatialis D, Pancreatic islet macroencapsulation using microwell porous membranes, Scientific Reports. 2017; 7(1):9186. DOI:10.1038/s41598-017-09647-7

    42. Buitinga M, Assen F, Hanegraaf M, Wieringa P, Hilderink J, Moroni L, Truckenmüller R, van Blitterswijk C,  Römer GW, Carlotti F,  de Koning E, Karperien M, van Apeldoorn A. Micro-fabricated scaffolds lead to efficient remission of diabetes in mice, Biomaterials. 2017; 135: 10-22. DOI:10.1016/j.biomaterials.2017.03.031

    41. Smink AM, Li S, Swart HD, Hertsig DT, de Haan BJ, Kamps JAAM, Schwab L, van Apeldoorn AA, de Koning E, Faas MM, Lakey JRT, de Vos P. Stimulation of vascularization of a subcutaneous scaffold applicable for pancreatic islet-transplantation enhances immediate post-transplant islet graft function but not long-term normoglycemia, Journal of Biomedical Materials Research Part A. 2017; 105(9): 2533–2542. DOI: 10.1002/jbm.a.36101

    40. Smink AM, Li S, Hertsig DT, de Haan BJ, Schwab L, van Apeldoorn AA, de Koning E, Faas MM, Lakey JRT, de Vos P. The efficacy of a prevascularized, retrievable Poly(D,L,-lactide-co-ε-caprolactone) subcutaneous scaffold as transplantation site for pancreatic islets, Transplantation. 2017; 101(4): e112–e119. DOI: 10.1097/TP.0000000000001663


    39. Henke S, Leijten J, Kemna E, Neubauer M, Fery A, van den Berg A, van Apeldoorn A, Karperien M. Enzymatic Crosslinking of Polymer Conjugates is Superior over Ionic or UV Crosslinking for the On-Chip Production of Cell-Laden Microgels. Macromolecular Bioscience. 2016 Jul 21. [Epub ahead of print]. DOI: 10.1002/mabi.201600174

    38. Smink AM, Hertsig DT, Schwab L, van Apeldoorn AA, de Koning E, Faas MM, de Haan BJ, de Vos P. A Retrievable, Efficacious Polymeric Scaffold for Subcutaneous Transplantation of Rat Pancreatic Islets. Annals of Surgery 2016 Jul 15. [Epub ahead of print]

    37. Smink AM, de Haan BJ, Paredes-Juarez GA, Wolters AHG, Kuipers J, Giepmans BNG, Schwab LEngelse M Avan Apeldoorn AA, de Koning EFaas MMde Vos P. Selection of polymers for application in scaffolds applicable for human pancreatic islet transplantationBiomedical Materials 2016; 11(3):035006. DOI: 10.1088/1748-6041/11/3/035006

    36. Buitinga M, Janeczek Portalska K, Cornelissen D, Plass J, Hanegraaf M, Carlotti F, de Koning EJP, Engelse MA, van Blitterswijk CA, Karperien M, van Apeldoorn AA, de Boer J. Coculturing human islets with proangiogenic support cells to improve islet revascularization at the subcutaneous transplantation site. Tissue Engineering Part A 2016; 22(3-4):375-385DOI:10.1089/ten.TEA.2015.0317


    35. Steins A, Dik P, Müller WH, Vervoort SJ, Reimers K, Kuhbier JW, Vogt PM, van Apeldoorn AA, Coffer PJ, Schepers K. In vitro evaluation of spider silk meshes as a potential biomaterial for bladder reconstruction. PLOS One 2015; 10(12): e0145240. DOI:10.1371/journal.pone.0145240

    34. Marchioli G, van Gurp L, van Krieken PP, Stamatialis D, Engelse M, van Blitterswijk CA, Karperien M, de Koning E, Alblas J, Moroni L, van Apeldoorn AA. Fabrication of three-dimensional bioplotted hydrogel scaffolds for islets of Langerhans transplantation. Biofabrication 2015; 7(2): 025009. DOI:10.1088/1758-5090/7/2/025009

    33. Hujaya SD, Marchioli G, Roelofs K, van Apeldoorn AA, Moroni L, Karperien M, Paulusse JMJ, Engbersen JFJ. Poly(amido amine)-based multilayered thin films on 2D and 3D supports for surface-mediated cell transfection. Journal of Controlled Release 2015; 205: 181189. DOI: 10.1016/j.jconrel.2015.01.034 

    32. Manohar S, van Apeldoorn A, Steenbergen W. Photoacoustic imaging: Cells make themselves heard. Nature Photonics 2015; 9: 216-218(215). DOI:10.1038/nphoton.2015.46

    31. Hilderink J,Spijker S, Carlotti F, Lange L, Engelse MA, van Blitterswijk CA, de Koning EJP, Karperien M,  van Apeldoorn AA. Controlled aggregation of primary human pancreatic islet cells leads to glucose-responsive pseudoislets comparable to native islets. Journal of Cellular and Molecular Medicine 2015; 19(8): 1836–1846. DOI:10.1111/jcmm.12555


    30. Gevaert E, Dolle ́ L, Billiet T, Dubruel P, van Grunsven L, van Apeldoorn AA, Cornelissen R. High throughput micro-well generation of hepatocyte micro-aggregates for tissue engineering. PLOS ONE 2014; 9(8): e105171. DOI:10.1371/journal.pone.0105171


    29. Hilderink J, Otto C, Slump C, Lenferink A, Engelse M, van Blitterswijk C, de Koning E, Karperien M, van Apeldoorn AA. Label-free detection of insulin and glucagon within human islets of Langerhans using Raman spectroscopy. PLOS ONE  2013; 8(10): e78148.  DOI:10.1371/journal.pone.0078148

    28. Buitinga M, Truckenmüller R, Engelse MA, Moroni L, ten Hoopen HWM, van Blitterswijk CA, de Koning EJP, van Apeldoorn AA, Karperien M. Microwell scaffolds for the extrahepatic transplantation of islets of Langerhans. PLOS ONE 2013; 8(5):e64772. DOI:10.1371/journal.pone.0064772.

    27. Kunstar A, Leferink AM, Okagbare PI, Morris MD, Roessler BJ, Otto C, Karperien M, van Blitterswijk CA, Moroni L, van Apeldoorn AA. Label-free Raman monitoring of extracellular matrix formation in three-dimensional polymeric scaffolds. Journal of The Royal Society Interface 2013; 10(86):20130464. DOI: 10.1098/​rsif.2013.0464.

    26. Wissing T B, van Apeldoorn AA, Ijzerman M J. The expected value of bio-artificial pancreas development in view of endocrinologists' and patients' preferences. Value in Health 2013; 16(3):A169. DOI: 10.1016/j.jval.2013.03.845.

    25. Spijker HS, Ravelli RBG, Mieke Mommaas-Kienhuis A, van Apeldoorn AA, Engelse MA, Zaldumbide A, Bonner-Weir S, Rabelink TJ, Hoeben RC, Clevers H, Mummery CL, Carlotti F, de Koning EJP. Conversion of mature human β-cells into glucagon-producing α-cells. Diabetes 2013; 62(7):2471-80. DOI:10.2337/db12-1001.

    24. Doorn J, Roberts SJ, Hilderink J, Groen N, van Apeldoorn AA, van Blitterswijk C,  Schrooten J, de Boer J. Insulin-like-growth-factor-I enhances proliferation and differentiation of human mesenchymal stromal cells in vitro. Tissue Engineering Part A 2013; 19(15-16):1817-1828. DOI:10.1089/ten.TEA.2012.0522.

    23. Spitters TWGM , Leijten JCH, Deus FP, Costa IBF, van Apeldoorn AA, van Blitterswijk C, Karperien M. A dual flow bioreactor with controlled mechanical stimulation for cartilage tissue engineering. Tissue Engineering Part C-Methods 2013; 19(10):774-783. DOI:10.1089/ten.TEC.2012.0435

    22. Masaeli E, Morshed M, Hossein Nasr-Esfahani M, Sadri S, Hilderink J, van Apeldoorn AA, van Blitterswijk CA, Moroni L. Fabrication, characterization and cellular compatibility of poly(hydroxy alkanoate) composite nanofibrous scaffolds for nerve tissue engineering. PLOS ONE 2013; 8(2):e57157. DOI:10.1371/journal.pone.0057157

    21. Basalus MWZ, Tandjung K, Sen H, van Apeldoorn AA, Grijpma DW, von Birgelen C. Recent insights from scanning electron microscopic assessment of durable polymer-coated drug-eluting stents. Interventional Cardiology 2012; 4(6):661-674. DOI: 10.2217/ica.12.67

    20. Lourenco BN, Marchioli G, Song W, Reis RL, van Blitterswijk CA, Karperien M, van Apeldoorn AA, Mano JF. Wettability influences cell behavior on superhydrophobic surfaces with different topographies. Biointerfaces 2012; 7(1-4):46. PMID: 22833364    

    19. Berenschot EJ, Burouni N, Schurink B, van Honschoten JW, Sanders RG, Truckenmuller R, Jansen HV, Elwenspoek MC, van Apeldoorn AA, Tas NR. 3D Nanofabrication of Fluidic Components by Corner Lithography. Small 2012; 8(24):3823-3831. PMID: 22907803

    18. Kunstar A, Leijten J, van Leuveren S, Hilderink J, Otto C, van Blitterswijk CA, Karperien M, van Apeldoorn AA. Recognizing different tissues in human fetal femur cartilage by label-free Raman microspectroscopy. Journal of Biomedical Optics 2012; 17(11):116012. PMID: 23117807

    17. Moreira Teixeira LS, Leijten JCH, Sobral J, Jin R, van Apeldoorn AA, Feijen J, van Blitterswijk C, Dijkstra PJ, Karperien M. High throughput generated micro-aggregates of chondrocytes stimulate cartilage formation in vitro and in vivo. European Cells & Materials 2012; 34:387-399. PMID: 22665161

    16. Lopez-Heredia MA, Sariibrahimoglu K, Yang W, Bohner M, Yamashita D, Kunstar A, van Apeldoorn AA, Bronkhorst EM, Lanao RP, Leeuwenburgh SC, Itatani K, Yang F, Salmon P, Wolke JG, Jansen JA. Influence of the pore generator on the evolution of the mechanical properties and the porosity and interconnectivity of a calcium phosphate cement. Acta Biomaterialia 2012; 8(1):404-414. PMID: 21884833

    15. Basalus MW, Tandjung K, van Westen T, Sen H, van der Jagt PK, Grijpma DW, van Apeldoorn AA, von Birgelen C. Scanning electron microscopic assessment of coating irregularities and their precursors in unexpanded durable polymer-based drug-eluting stents. Catheterization and Cardiovascular Interventions 2012; 79(4):644-653. PMID: 21805599


    14. Hazekamp J, Reed MG, Howard CV, van Apeldoorn AA, Otto C. The feasibility of Cryo In-SEM Raman microspectroscopy. Journal of Microscopy 2011; 244(2):122–128. PMID: 21696391

    13. Kunstar A, Otto C, Karperien M, van Blitterswijk C, van Apeldoorn A. Raman microspectroscopy: a noninvasive analysis tool for monitoring of collagen-containing extracellular matrix formation in a medium- throughput culture system. Tissue Engineering Part C: Methods 2011; 17(7):737–744. 
    PMID: 21410304

    12. Basalus MWZ, Tandjung K, van Apeldoorn AA, Ankone MJK, Birgelen von C. Effect of oversized partial postdilatation on coatings of contemporary durable polymer-based drug-eluting stents: a scanning electron microscopy study. Journal of Interventional Cardiology 2011; 24(2):149–161. PMID: 21198852

    11. Both SK, van Apeldoorn AA, Jukes JM, Englund MC, Hyllner J, van Blitterswijk CA, de Boer J. Differential bone-forming capacity of osteogenic cells from either embryonic stem cells or bone marrow-derived mesenchymal stem cells. Journal of Tissue Engineering and Regenerative Medicine 2011; 5(3):180–190. PMID: 20718035

    2007 and earlier 

    10. van Manen H-J, van Apeldoorn AA, Verrijk R, van Blitterswijk CA, Otto C. Intracellular degradation of microspheres based on cross-linked dextran hydrogels or amphiphilic block copolymers: a comparative raman microscopy study. International Journal of Nanomedicine 2007; 2(2):241–252. PMID: 

    9. van Apeldoorn AA, de Boer J, van Steeg H, Hoeijmakers JHJ, Otto C, van Blitterswijk CA. Physicochemical composition of osteoporotic bone in the trichothiodystrophy premature aging mouse determined by confocal Raman microscopy. Journal of Gerontology: Medical Sciences 2007; 62(1):34–40. PMID: 17301035

    8. van Manen H-J, van Apeldoorn AA, Roos D, Otto C. Raman microscopy of phagocytosis: shedding light on macrophage foam cell formation. SPIE Proceedings 2006; 6093:122-130.

    7. Wang J, van Apeldoorn AA, de Groot K. Electrolytic deposition of calcium phosphate/chitosan coating on titanium alloy: growth kinetics and influence of current density, acetic acid, and chitosan. Journal of Biomedical Materials Research Part A 2006; 76(3):503–511. PMID: 16278873

    6. van Apeldoorn AA, Aksenov Y, Stigter M, Hofland I, de Bruijn JD, Koerten HK, Otto C, Greve J, van Blitterswijk CA. Parallel high-resolution confocal Raman SEM analysis of inorganic and organic bone matrix constituents. Journal of the Royal Society: Interface 2005; 2(2):39–45. PMID: 

    5. van Apeldoorn AA, van Manen H-J, Bezemer JM, de Bruijn JD, van Blitterswijk CA, Otto C. Raman imaging of PLGA microsphere degradation inside macrophages. Journal of the Americal Chemical Society 2004; 126(41):13226–13227. PMID: 15479068

    4. de Boer J, Siddappa R, Gaspar C, van Apeldoorn A, Fodde R, van Blitterswijk C. Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells. Bone 2004; 34(5):818–826. PMID: 15121013

    3. Deschamps AA, van Apeldoorn AA, Hayen H, de Bruijn JD, Karst U, Grijpma DW, Feijen J. In vivo and in vitro degradation of poly(ether ester) block copolymers based on poly(ethylene glycol) and poly(butylene terephthalate). Biomaterials 2004; 25(2):247–258. PMID: 14585712

    2. Deschamps AA, van Apeldoorn AA, de Bruijn JD, Grijpma DW, Feijen J. Poly(ether ester amide)s for tissue engineering. Biomaterials 2003; 24(15):2643–2652. PMID: 12726718

    1. Alonso A, van Apeldoorn AA, Banuelos M, Barrutia MG, Zapata ZG. Antibody-forming cells (AFCs) in the lung lymphoid tissue after primary and secondary immunization through different routes: a semiquantitative analysis in adult rats using T-dependent (TNP-KLH) and T-independent antigens (TNP-LPS). Advances in Experimental Medicine and Biology 1994; 355:277–281. PMID: 7709836